For Clinicians.

EasyM uses a mass spectrometry based technique for Minimal Residual Disease (MRD) testing in patients with Multiple Myeloma. MRD status is now considered by the majority of clinicians to be the most valuable prognostic tool.

EasyM uses a mass spectrometry based technique for Minimal Residual Disease (MRD) testing in patients with Multiple Myeloma. MRD status is now considered by the majority of clinicians to be the most valuable prognostic tool.

For Clinical Trials.

There is no defined standard of care associated with MRD status and there is no standard approach for MRD testing. Some methods (e.g. SPEP, IFE) are accessible but not sensitive; others (e.g. flow cytometry, NGS) are sensitive, but require bone marrow aspiration. To overcome these challenges and to complement other approaches, mass spectrometry-based assays have been developed to monitor the presence of monoclonal immunoglobulin (M-Protein) in the serum of patients. Of the mass spectrometry-based techniques, the clonotypic peptide approach (i.e. monitoring the patient-specific sequence) is considered to be more sensitive than monitoring the intact molecule or chain. EasyM is the first assay to overcome the challenges of throughput, speed, and applicability of the clonotypic peptide mass spectrometry-based technique.

For an overview of MRD monitoring in Multiple Myeloma, we recommend
Kostopoulos et al., Minimal Residual Disease in Multiple Myeloma: Current Landscape and Future Applications With Immunotherapeutic Approaches. Front Oncol. 2020 May 27;10:860. doi: 10.3389/fonc.2020.00860. PMID: 32537439; PMCID: PMC7267070.

For clinical collaborations
The Multiple Myeloma community benefits from exploration of MRD techniques using real-world clinical data. If you are interested in collaborating with us on a paper or publication to explore the utility, comparative strengths, and the applicability of MRD monitoring techniques for clinical decisions and outcomes, please contact us. We may be able to support your clinical study with free EasyM testing through our early access program.

Clinical Use.

EasyM has been approved as a Laboratory Developed Test (LDT) by CLIA/COLA in all US states except CA, NY, RI, PA and MD. We are seeking further certification in the remaining states, by the US FDA and by Health Canada.

For a limited time, physicians are invited to participate in our EasyM Physician Experience Program for early access to the EasyM assay. If interested in participating, please inquire here

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