Introduction Minimal residual disease (MRD) has emerged as a critical prognostic marker in multiple myeloma (MM). Traditional MRD assessment relies heavily on bone marrow–based methods such as multiparameter flow cytometry (MFC), next-generation flow cytometry (NGF), and next-generation sequencing (NGS). However, these are invasive, costly, and limited in their ability to capture disease [...]

Zac McDonald, Paul Taylor, Mariya Liyasova, Qixin Liu, Bin Ma DOI: 10.1021/acs.jproteome.0c01022 Publication Summary The amino acid sequence of the M-protein for multiple myeloma is unique compared to the polyclonal antibodies in patients’ blood. This uniqueness is exploited to develop an ultrasensitive M-protein detection method utilizing mass spectrometry (MS). This study demonstrates [...]